Alterations in the Rabbit Lymphoid Tissues and Selected Parameters of Homeostasis after Bendiocarb Administration

The carbamate compounds are a class of cholinesterase inhibiting pesticides, and bendiocarb is the most widely used carbamate insecticide used to control disease vectors (mosquitoes, flies, household and agricultural pests). In this study histological structure of rabbit lymphoid tissue and selected parameters of homeostasis after bendiocarb administration were studied. Bendiocarb was perorally administered for 60 days (D60). The structure of intestinal wall of experimental animals revealed any significant changes. In the small intestine a slight increase in the height of enterocytes and diameter of crypts was detected indicating increased cellular activity. More detailed analysis of Peyer’s patches in experimental groups after administration of bendiocarb revealed a relative decrease in areas rich in lymphocytes. Observations of the lymph node showed that on D10 and D20 there was a significant increase in relative volume of medulla at the expense of the relative volume of the cortex and a decrease in the number of lymphocytes. However, we recorded an increase in diameter of lymphocytes. Bendiocarb addition caused imbalance in internal milieu of rabbits. Main changes were observed in serum creatinine content and activity of serum enzymes (creatinine and GGT on D30, AST on D10 and D30, and GLUD on D10) describing possible failure of liver and/or kidney caused by bendiocarb. Decrease of some hematological parameters (hematocrit, mean corpuscular haemoglobin concentration, platelet count) in all experimental groups suggests possible significant defection in haemoplastic system.